Back when computers were a novelty, we had schools dedicated to teaching people how to use them in my country.
The classes ranged from the most basic stuff, such as how to use a mouse, to more advanced topics, such as how to use the Windows registry.
We might need to bring these schools back in the near future.
I had the same experience.
Up to room 46, it felt like every failed run built up to your eventual success, like any good roguelite. You failed, but at least gained a bit of knowledge, a permanent upgrade or improvement to the state.
Then you get to a point where each run is less and less rewarding and eventually give up. There’s nothing left to learn or upgrade, it’s now a fight with the RNG.